Associate Professor of Medicine
Associate Professor of Molecular Microbiology
Associate Professor of Pathology and Immunology
Washington University School of Medicine
Office Phone Number: 314-286-0857
Lab Phone Number: 314-286-1522
Host-pathogen interactions, influenza virus, viral pathogenesis, Bourbon virus, RNA biology, influenza reassortment, SARS-CoV-2, COVID-19
Dr. Boon received his Ph.D. in 2003 from the Erasmus University in Rotterdam, the Netherlands. In the lab of Dr. Albert Osterhaus, a world-renowned virologist, and Dr. Guus Rimmelzwaan, he investigated human T-cell immunity to influenza viruses. He demonstrated that the magnitude and specificity of the CTL response in humans is related to the HLA class I genotype. He also applied his skills to use influenza virus as a vector for antigen delivery during vaccination.
As a post-doctoral fellow in the lab of Dr. Richard Webby at St Jude Children’s Research Hospital in Memphis, TN, he identified the significance of host genetic polymorphisms on susceptibility to highly pathogenic H5N1 influenza virus. He was also involved in H5N1 transmission studies, monoclonal antibody therapy to H5N1 virus and in identifying the protective role of neuraminidase specific antibodies. Finally, he established a new mouse model for studying avian influenza viruses.
Currently Dr. Boon is an Associate Professor at Washington University School of Medicine in St Louis where he works on RNA viruses including influenza virus, Bourbon virus and SARS-CoV-2, as well as viral pathogenesis. In this capacity he is also responsible for the facility dedicated to studies on highly pathogenic H5N1 influenza virus. Dr. Boon’s has published more than 50 manuscripts in peer-reviewed journals. He was awarded two young investigator awards and was the recipient of the Barrett Post-doctoral Fellowship.