View Dr. Boon’s publications on pubmed


Bricker TL, Darling TL, Hassan AO, Harastani HH, Soung A, Jiang X, Dai YN, Zhao H, Adams LJ, Holtzman MJ, Bailey AL, Case JB, Fremont DH, Klein R, Diamond MS, Boon ACM. A single intranasal or intramuscular immunization with chimpanzee adenovirus-vectored SARS-CoV-2 vaccine protects against pneumonia in hamsters. Cell Rep. 2021 Jun 29:109400.

Chen RE, Winkler ES, Case JB, Aziati ID, Bricker TL, Joshi A, Darling TL, Ying B, Errico JM, Shrihari S, VanBlargan LA, Xie X, Gilchuk P, Zost SJ, Droit L, Liu Z, Stumpf S, Wang D, Handley SA, Stine WB Jr, Shi PY, Davis-Gardner ME, Suthar MS, Knight MG, Andino R, Chiu CY, Ellebedy AH, Fremont DH, Whelan SPJ, Crowe JE Jr, Purcell L, Corti D, Boon ACM, Diamond MS. In vivo monoclonal antibody efficacy against SARS-CoV-2 variant strains. Nature. 2021 Jun 21

Schmitz AJ, Turner JS, Liu Z, Aziati ID, Chen RE, Joshi A, Bricker TL, Darling TL, Adelsberg DC, Alsoussi WB, Case JB, Lei T, Thapa M, Amanat F, O’Halloran JA, Shi PY, Presti RM, Krammer F, Bajic G, Whelan SPJ, Diamond MS, Boon ACM, Ellebedy AH. A public vaccine-induced human antibody protects against SARS-CoV-2 and emerging variants. bioRxiv. 2021 Mar 24:2021

Winkler ES, Gilchuk P, Yu J, Bailey AL, Chen RE, Chong Z, Zost SJ, Jang H, Huang Y, Allen JD, Case JB, Sutton RE, Carnahan RH, Darling TL, Boon ACM, Mack M, Head RD, Ross TM, Crowe JE Jr, Diamond MS. Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions for optimal therapeutic protection. Cell. 2021 Apr 1;184(7):1804-1820.e16

Chen RE, Zhang X, Case JB, Winkler ES, Liu Y, VanBlargan LA, Liu J, Errico JM, Xie X, Suryadevara N, Gilchuk P, Zost SJ, Tahan S, Droit L, Turner JS, Kim W, Schmitz AJ, Thapa M, Wang D, Boon ACM, Presti RM, O’Halloran JA, Kim AHJ, Deepak P, Pinto D, Fremont DH, Crowe JE Jr, Corti D, Virgin HW, Ellebedy AH, Shi PY, Diamond MS. Resistance of SARS-CoV-2 variants to neutralization by monoclonal and serum-derived polyclonal antibodies. Nat Med. 2021 Apr;27(4):717-726


Son J, Huang S, Zeng Q, Bricker TL, Case JB, Zhou J, Zang R, Liu Z, Chang X, Harastani HH, Chen L, Gomez Castro MF, Zhao Y, Kohio HP, Hou G, Fan B, Niu B, Guo R, Rothlauf PW, Bailey AL, Wang X, Shi PY, Whelan SPJ, Diamond MS, Boon ACM, Li B, Ding S. Nitazoxanide and JIB-04 have broad-spectrum antiviral activity and inhibit SARS-CoV-2 replication in cell culture and coronavirus pathogenesis in a pig model. bioRxiv. 2020 Sep 25

Mudd PA, Crawford JC, Turner JS, Souquette A, Reynolds D, Bender D, Bosanquet JP, Anand NJ, Striker DA, Martin RS, Boon ACM, House SL, Remy KE, Hotchkiss RS, Presti RM, OHalloran JA, Powderly WG, Thomas PG, Ellebedy AH (2020).Distinct inflammatory profiles distinguish COVID-19 from influenza with limited contributions from cytokine storm. Sci Adv. 2020 Dec 9;6(50)

Swaim CD, Perng YC, Zhao X, Canadeo LA, Harastani HH, Darling TL, Boon ACM, Lenschow DJ, Huibregtse JM (2020). 6-Thioguanine blocks SARS-CoV-2 replication by inhibition of PLpro protease activities. bioRxiv, 2020

Shema Mugisha C, Vuong HR, Puray-Chavez M, Bailey AL, Fox JM, Chen RE, Wessel AW, Scott JM, Harastani HH, Boon ACM, Shin H, Kutluay SB. A Simplified Quantitative Real-Time PCR Assay for Monitoring SARS-CoV-2 Growth in Cell Culture. mSphere, 2020;5(5):e00658-20

Tran V, Ledwith MP, Thamamongood T, Higgins CA, Tripathi S, Chang MW, Benner C, García-Sastre A, Schwemmle M, Boon ACM, Diamond MS, Mehle A. Influenza virus repurposes the antiviral protein IFIT2 to promote translation of viral mRNAs. Nature Microbiology, 2020

Hong JP, Reynoso GV, Andhey PS, Swain A, Turner JS, Boon ACM, Krammer F, Ellebedy AH, Zanini F, Artyomov M, Hickman HD, Diamond MS (2020). An Agonistic Anti-CD137 Antibody Disrupts Lymphoid Follicle Structure and T-Cell-Dependent Antibody Responses. Cell Reports Medicine, 2020;1(3):100035


Jash A, Zhou YW, Gerardo DK, Ripperger TJ, Parikh BA, Piersma S, Jamwal DR, Kiela PR, Boon ACM, Yokoyama WM, Hsieh CS, Bhattacharya D (2019). ZBTB32 restrains antibody responses to murine cytomegalovirus infections, but not other repetitive challenges. Scientific Reports, 2019; 9(1):15257

Peterson ST, Kennedy EA, Brigleb PH, Taylor GM, Urbanek K, Bricker TL, Lee S, Shin H, Dermody TS, Boon ACM, Baldridge MT (2019). Disruption of Type III Interferon (IFN) genes Ifnl2 and Ifnl3 recapitulates loss of the type III IFN Receptr in the mucosal antiviral response. Journal of Virology, 2019;93(22):e01073-19

Bricker TL, Shafiuddin M, Gounder AP, Janowski AB, Zhao G, Williams GD, Jagger BW, Diamond MS, Bailey T, Kwon JH, Wang D, Boon ACM (2019). Therapeutic efficacy of Favipiravir against Bourbon virus in mice. PLoS Pathogens, 2019;15(6):e1007790

Shafiuddin M, Boon ACM (2019). RNA sequence features are at the core of influenza A virus genome packaging. Journal of Molecular Biology. 2019 Mar 23

Gounder AP, Boon ACM (2019). Influenza Pathogenesis: The effect of host factors on severity of disease. Journal of Immunology, 2019; 202(2):341-350

Lauron EJ, Yang L, Harvey IB, Sojka DK, Williams GD, Paley MA, Bern MD, Park E, Victorino F, Boon ACM, Yokoyama WM (2019). Viral MHC-I inhibition evades tissue-resident memory T cell formation and responses. Journal of Experimental Medicine, 2019; 216(1):117-132


Gounder AP, Yokoyama CC, Jarjour NN, Bricker TL, Edelson BT, and Boon ACM (2018). Interferon induced protein 35 exacerbates H5N1 influenza disease through the expression of IL-12p40 homodimer. PLoS Pathogens; 14(4):e1007001.

Williams GD, Townsend D, Wylie C, Amarasinghe GK, Kutluay SB, Boon ACM (2018). Nucleotide resolution mapping of influenza A virus nucleoprotein-RNA interactions reveals the landscape of viral RNA features required for replication. Nature Communications; 9(1):465.

Nair S, Huynh JP, Lampropoulou V, Loginicheva E, Esaulova E, Gounder AP, Boon ACM, Schwarzkopf EA, Bradstreet TR, Edelson BT, Artyomov MN, Stallings CL, Diamond MS (2018). Irg1 expression in myeloid cells prevents immunopathology during M. tuberculosis infection. Journal of Experimental Medicine; 215(4):1035-1045.

Li J., Leavey A., Wang Y., O’Neil C., Wallace M., Burnham C., Boon A.C.M., Babcock H., Biswas P (2018). Comparing the performance of 3 bioaerosol samplers for influenza virus. Journal of Aerosol Science. 2018. 133-145


Steed AL, Christophi GP, Kaiko GE, Sun L, Goodwin VM, Jain U, Esaulova E, Artyomov MN, Morales DJ, Holtzman MJ, Boon ACM, Lenschow DJ, Stappenbeck TS (2017). The microbial metabolite desaminotyrosine protects from influenza through type I interferon. Science (4); 357(6350):498-502.


DesRochers BL, Chen RE, Gounder AP, Pinto AK, Bricker T, Linton CN, Rogers CD, Williams GD, Webby RJ, Boon ACM (2016). Residues in the PB2 and PA genes contribute to the pathogenicity of avian H7N3 influenza A virus in DBA/2 mice. Virology, 2016;494:89-99

Williams GD, Pinto AK, Doll B, Boon ACM (2016). A North American H7N3 Influenza Virus Supports Reassortment with 2009 Pandemic H1N1 and Induces Disease in Mice without Prior Adaptation. Journal of Virology. 14;90(9):4796-806

Lu Q, Yokoyama CC, Williams JW, Baldridge MT, Jin X, DesRochers B, Bricker T, Wilen CB, Bagaitkar J, Loginicheva E, Sergushichev A, Kreamalmeyer D, Keller BC, Zhao Y, Kambal A, Green DR, Martinez J, Dinauer MC, Holtzman MJ, Crouch EC, Beatty W, Boon ACM, Zhang H, Randolph GJ, Artyomov MN, Virgin HW. (2016). Homeostatic Control of Innate Lung Inflammation by Vici Syndrome Gene Epg5 and Additional Autophagy Genes Promotes Influenza Pathogenesis. Cell Host and Microbe. 13;19(1):102-13


Pinto AK, Williams GD, Szretter KJ, White JP, Proença-Módena JL, Liu G, Olejnik J, Brien JD, Ebihara H, Mühlberger E, Amarasinghe G, Diamond MS, Boon ACM (2015). Human and Murine IFIT1 Proteins Do Not Restrict Infection of Negative-Sense RNA Viruses of the Orthomyxoviridae, Bunyaviridae, and Filoviridae Families. Journal of Virology, 89(18):9465-76.

Zanin M, Keck ZY, Rainey GJ, Lam CY, Boon ACM, Rubrum A, Darnell D, Wong SS, Griffin Y, Xia J, Webster RG, Webby RJ, Johnson S, Foung S (2015). An anti-H5N1 influenza virus FcDART antibody is a highly efficacious therapeutic agent and prophylactic against H5N1 influenza virus infection. Journal of Virology. 2015; 89:4549-61.

Boon A.C.M, Williams R.W., Sinasac D.S., Webby R.J. A novel genetic locus linked to pro-inflammatory cytokines after virulent H5N1 virus infection in mice. BMC Genomics. 2014. 15:1017.

Hillaire M.L., Nieuwkoop N.J., Boon A.C.M., de Mutsert G., Vogelzang-van Trierum S.E., Fouchier R.A., Osterhaus A.D., Rimmelzwaan G.F. Binding of DC-SIGN to the hemagglutinin of influenza A viruses supports virus replication in DC-SIGN expressing cells. PLoS One. 2013. 8(2).

Sun Z., Huber V.C., McCormick K., Kaushik R.S., Boon A.C.M., Zhu L., Hause B., Webby R.J, Fang Y.. Characterization of a porcine intestinal epithelial cell line for influenza virus production. Journal of General Virology. 2012 Jun 27.

Cai Z., Ducatez M.F., Yang J., Zhang T., Long L.P., Boon A.C.M., Webby R.J., Wan X.F. Identifying Antigenicity-Associated Sites in Highly Pathogenic H5N1 Influenza Virus Hemagglutinin by Using Sparse Learning. Journal of Molecular Biology. 2012 Sep 7;422(1):145-55.

Marcelin G., Aldridge J.R., Duan S., Ghoneim H.E., Rehg J., Marjuki H., Boon A.C.M, McCullers J.A., Webby R.J. Fatal outcome of pandemic H1N1 2009 influenza virus infection is associated with immunopathology and impaired lung repair, not enhanced viral burden, in pregnant mice. Journal of Virology. 2011 85(21):11208-19.

Boon A.C.M., Finkelstein D., Zheng M., Liao G., Allard J., Klumpp K., Webster R.G., Peltz G., Webby R.J. 2011. H5N1 Influenza Virus Pathogenesis in Genetically Diverse Mice Is Mediated at the Level of Viral Load. mBio. 2011 Sep 6;2(5).

Evseenko V.A., Boon A.C.M., Brockwell-Staats C., Franks J., Rubrum R., Daniels C.S., Gramer M.R. and Webby R.J. 2011. Genetic composition of contemporary swine influenza viruses in the West Central region of the United States of America. Influenza and Other Respiratory Viruses. 5(3):188-97.

Boon A.C.M., DeBeauchamp J., Krauss S., Rubrum A., Webb A., Webster R.G., McElhaney J., Webby R.J. Cross-reactive neutralizing antibodies directed against pandemic H1N1 2009 virus are protective in a highly sensitive DBA/2 mouse influenza model Journal of Virology 2010. 84:7662-7.


Boon A.C.M., DeBeauchamp J., Hollmann A., Luke J., Finkelstein D., Neale G., Rowe S., Kotb M., Lu L., Williams R.W., Webby R.J. Host Genetic Variation Affects Resistance to Infection with a Highly Pathogenic H5N1 Influenza A Virus in mice. Journal of Virology 2009. 83:10417-26.

Yen H.L., Aldridge J., Boon A.C.M., Ilyushina N.A., Salomon R., Hulse-Post D., Marjuki H., Franks J., Boltz D., Bush D., Lipatov A., Rehg J., Webby R.J., Webster R.G. Changes in the H5N1 influenza virus hemagglutinin receptor binding domain affect systemic spread. PNAS 2009. 106:286-291.

Sandbulte M.R., Boon A.C.M., Webby R.J., Riberdy J.M. Analysis of cytokine secretion from human plasmacytoid dendritic cells infected with H5N1 or low-pathogenicity influenza viruses. Virology 2008. 381:22-28.

Ilyushina N.A., Hay A., Yilmaz N., Boon A.C.M., Webster R.G., Govorkova E.A. Oseltamivir-ribavirin combination therapy for highly pathogenic H5N1 influenza virus infection in mice. Antimicrobial Agents Chemotherapy 2008. 52:3889-97.

Rimmelzwaan G.F., Nieuwkoop N.J., de Mutsert G., Boon A.C.M., Kuiken T., Fouchier R.A., Osterhaus A.D. Attachment of infectious influenza A viruses of various subtypes to live mammalian and avian cells as measured by flow cytometry. Virus Research 2007. 129:175-81.

Boon A.C.M., Sandbulte M.R., Seiler J.P., Webby R.J., Songserm T., Guan Y., Webster R.G. The role of terrestrial wild birds in the ecology of H5N1 influenza A virus. Emerging Infectious Diseases 2007. 13:1720-4.

Sandbulte M.R., Jimenez G.S., Boon A.C.M., Smith L.R., Treanor J.J., Webby R.J. Cross-Reactive Neuraminidase Antibodies afford partial protection against H5N1 in mice and are present in unexposed humans. PLoS Medicine 2007. 4:e59.

Hanson B.J., Boon A.C.M., Lim A.P., Webb A., Ooi E.E., Webby R.J. Passive immunoprophylaxis and therapy with humanized monoclonal antibody specific for influenza A H5 hemagglutinin in mice. Respiratory Research 2006. 14;7:126.

Berkhoff E.G, de Wit E., Geelhoed-Mieras M.M., Boon A.C.M., Symons J., Fouchier R.A.M, Osterhaus A.D.M.E, Rimmelzwaan G.F. Fitness costs limit escape from cytotoxic T lymphocytes by influenza A viruses. Vaccine 2006. 24:6594-6.

Boon A.C.M., de Mutsert G., Fouchier R.A.M, Osterhaus A.D.M.E., Rimmelzwaan G.F. The hypervariable immunodominant NP418-426 epitope from the influenza A virus nucleoprotein is recognized by cytotoxic T lymphocytes with high functional avidity. Journal of Virology 2006. 80:6024-32.

Berkhoff E.G.M., de Wit E., Geelhoed-Mieras M.M., Boon A.C.M., Symons J, Fouchier R.A.M., Osterhaus A.D.M.E., Rimmelzwaan G.F. Functional constraints of influenza A virus epitopes limit escape from cytotoxic T lymphocytes. Journal of Virology 2005. 79:11239-46.

van Baalen C.A., Kwa D., Verschuren E.J., Reedijk M.L., Boon A.C.M., de Mutsert G., Rimmelzwaan G.F., Osterhaus A.D.M.E., Gruters R.A. Fluorescent antigen-transfected target cell cytotoxic T lymphocyte assay for ex vivo detection of antigen-specific cell-mediated cytotoxicity. Journal of Infectious Diseases 2005. 192:1183-90.

Boon A.C.M., de Mutsert G., Fouchier R.A.M., Osterhaus A.D.M.E., Rimmelzwaan G.F. Functional profile of human influenza virus-specific cytotoxic T lymphocyte activity is influenced by interleukin-2 concentration and epitope specificity. Clinical and Experimental Immunology 2005. 142:45-52.

Boon A.C.M., de Mutsert G., van Baarle D., Smith D.J., Lapedes A.S., Fouchier R.A.M., Sintnicolaas K., Osterhaus A.D.M.E, Rimmelzwaan G.F. Recognition of homo- and heterosubtypic variants of influenza A viruses by human CD8+ T lymphocytes. Journal of Immunology 2004. 172; 2453-60.

Rimmelzwaan G.F., Boon A.C.M., Geelhoed-Mieras M.M., Voeten J.T.M., Fouchier R.A.M., Osterhaus A.D.M.E. Human airway epithelial cells present antigen to influenza virus-specific CD8+ CTL inefficiently after incubation with viral protein together with ISCOMATRIX®. Vaccine 2004. 29; 2769-75.

Rimmelzwaan G.F., Boon A.C.M., Voeten J.T.M., Berkhoff E.G.M., Fouchier R.A.M., Osterhaus A.D.M.E. Sequence variation in the influenza A virus nucleoprotein associated with escape from cytotoxic T lymphocytes. Virus Research 2004. 103; 97-100.

Berkhoff E.G.M., Boon A.C.M., Nieuwkoop N.J., Fouchier R.A.M., Sintnicolaas K., Osterhaus A.D.M.E., Rimmelzwaan G.F. The effect of a mutation in the HLA-B*2705-restricted NP383-391 epitope on the magnitude of the influenza A virus-specific CTL response in vitro. Journal of Virology 2004. 78; 5216-22.

Boon A.C.M., de Mutsert G., Fouchier R.A.M., Sintnicolaas K., Osterhaus A.D.M.E., Rimmelzwaan G.F. Preferential HLA usage in influenza virus specific CTL response. Journal of Immunology 2004. 172; 4435-43.


de Jong J.C., Palache A.M., Beyer W.E.P., Rimmelzwaan G.F., Boon A.C.M., Osterhaus A.D.M.E. Hemagglutination-inhibiting antibody to influenza virus. Developments in Biology (Basel) 2003. 115; 63-73.

Boon A.C.M., de Mutsert G., Graus Y.M.F., Fouchier R.A.M., Sintnicolaas K., Osterhaus A.D.M.E., Rimmelzwaan G.F. The magnitude and specificity of influenza A virus-specific CTL responses in humans is related to HLA-A and –B phenotype. Journal of Virology 2002. 76; 582-90.

Boon A.C.M., de Mutsert G., Graus Y.M.F., Fouchier R.A.M., Sintnicolaas K., Osterhaus A.D.M.E., Rimmelzwaan G.F. Sequence variation in a newly identified HLA-B35-restricted epitope in the influenza A virus nucleoprotein associated with escape from cytotoxic T lymphocytes. Journal of Virology 2002. 76; 2567-72.

Boon A.C.M., Fringuelli E., Graus Y.M.F., Fouchier R.A.M., Sintnicolaas K., Iorio A.M., Rimmelzwaan G.F., Osterhaus A.D.M.E. Influenza virus A specific T cell immunity in humans during aging. Virology 2002. 299; 100-8.

Boon A.C.M., Vos P., Graus Y.M.F., Rimmelzwaan G.F., Osterhaus A.D.M.E. In vitro effect of two dietary compounds on influenza virus-specific B and T cell responses. Scandinavian Journal of Immunology 2002. 55; 24-32.

Lawson T.M., Man S., Williams S., Boon A.C.M., Zambon M.C., Borysiewicz L.K. Influenza A antigen exposure selects dominant Vβ17+ T cell receptors in human CD8+ T cytotoxic T cell responses. International Immunology 2001. 13; 1373-81.

Boon A.C.M., French A.F., Fleming D.M., Zambon M.C. Detection of influenza a subtypes in community-based surveillance. Journal of Medical Virology 2001. 65; 163-170.

Irving W.L., James D.K., Stephenson T., Laing P., Jameson C., Oxford J.S., Chakraverty P., Brown D.G., Boon A.C.M., Zambon M.C. Influenza virus infection in the second and third trimesters of pregnancy: a clinical and seroepidemiological study. British Journal of Obstetrics and Gynaecology 2000. 107; 1282-1289.

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